Hemosuccus pancreaticus is an uncommon cause of upper gastrointestinal bleeding that can be challenging to diagnose and to manage.


Hemosuccus pancreaticus consists of bleeding from the pancreatic duct exiting into the duodenum through the ampulla of Vater.


Conditions associated with hemosuccus pancreaticus:

(1) acute pancreatitis

(2) chronic pancreatitis with or without pseudocyst

(3) trauma to the splenic artery

(4) aneurysm or pseudoaneurysm of the splenic artery

(5) mycotic aneurysm associated with infection

(6) iatrogenic injury from surgery or endoscopic ultrasound guided FNA

(7) pancreatic tumor

(8) arteriovenous malformation

(9) congenital malformation of the pancreas

(10) Glanzmann thrombasthenia


Differential diagnosis:

(1) hemobilia

(2) other causes of upper GI bleeding


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