Cutis laxa may occur for several reasons. Identifying the cause is essential for determining prognosis and planning therapy.


Criteria for cutis laxa:

(1) loosely hanging skin folds ("droopy skin") over most of the body

(2) degeneration of elastic fibers in the dermis

(3) variable degeneration of elastic fibers in other organs (which may determine prognosis)


Familial forms of cutis laxa:

(1) autosomal dominant

(2) autosomal recessive

(3) X-linked recessive


Hereditary disorders of connective tissue which can show cutis laxa:

(1) pseudoxanthoma elasticum

(2) DeBarsy's syndrome

(3) Patterson's syndrome

(4) "wrinkly skin" syndrome

(5) geroderma osteodysplastica


Acquired forms of cutis laxa:

(1) multiple myeloma and/or amyloidosis

(2) systemic lupus erythematosus (SLE)

(3) post-inflammatory elastolysis and cutis laxa (PECL), following a febrile illness

(4) drug-related


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