Criteria for cutis laxa:
(1) loosely hanging skin folds ("droopy skin") over most of the body
(2) degeneration of elastic fibers in the dermis
(3) variable degeneration of elastic fibers in other organs (which may determine prognosis)
Familial forms of cutis laxa:
(1) autosomal dominant
(2) autosomal recessive
(3) X-linked recessive
Hereditary disorders of connective tissue which can show cutis laxa:
(1) pseudoxanthoma elasticum
(2) DeBarsy's syndrome
(3) Patterson's syndrome
(4) "wrinkly skin" syndrome
(5) geroderma osteodysplastica
Acquired forms of cutis laxa:
(1) multiple myeloma and/or amyloidosis
(2) systemic lupus erythematosus (SLE)
(3) post-inflammatory elastolysis and cutis laxa (PECL), following a febrile illness
(4) drug-related
