A number of conditions may result in acquired defects in neutrophil function, which may be associated with an increased risk for infection.
Possible neutrophil dysfunctions:
(1) defects in adhesion
(2) defects in cytoplasmic granules
(3) defect in motility and chemotaxis
(4) defects in phagocytosis and killing (defect in oxidative metabolism, other)
bone marrow transplant
graft vs host disease
paroxysmal nocturnal hemoglobinuria (PNH)
sickle cell anemia
trauma and/or surgery
• Hematologic disorders include myelodysplasia, myeloproliferative disorders and AML.
• Chronic infections may be a chicken and egg situation (hard to know which came first) and may be associated with other conditions.
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Specialty: Hematology Oncology, Clinical Laboratory