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Composite Physiologic Index (CPI) of Wells et al in Idiopathic Pulmonary Fibrosis

Description

Wells et al reported the composite physiologic index (CPI) for patients with idiopathic pulmonary fibrosis. This can help to predict the extent of pulmonary fibrosis on high-reolution CT (HRCT). The authors are from Royal Brompton Hospital, King's College Hospital and Mayo Clinic.


Parameter:

(1) percent predicted DLco

(2) percent predicted FVC

(3) percent predicted FEV1

 

CPI = extent of disease on CT =

= 91.0 - (0.65 * (percent predicted DLco)) - (0.53 * (percent predicted FVC)) + (0.34 * (percent predicted FEV1))

 

Interpretation:

• minimum score: 7

• maximum score: around 80

• The higher the CPI the greater the extent of pulmonary fibrosis.

 

From Figure 4:

 

percent fibrosis on CT =

= (1.8868 * (CPI)) - 49.056


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