Following transplantation of hematopoietic progenitor cells (HPC) from an ABO or D incompatible donor there is a need to carefully select components for transfusion that reflect the patient's new antigenic status.
Components:
(1) red blood cell (RBC) products
(2) fresh frozen plasma (FFP) or platelets
(3) second choice for platelets
Selection of RBC Products
Recipient
HPC Donor ABO Type
ABO Type
O
A
B
AB
O
O
O
O
O
A
O
A
O
A
B
O
O
B
B
AB
O
A
B
AB
Selection of FFP or platelets
Recipient
HPC Donor ABO Type
ABO Type
O
A
B
AB
O
O
A
B
AB
A
A
A
AB
AB
B
B
AB
B
AB
AB
AB
AB
AB
AB
Selection of second choice platelets
Recipient
HPC Donor ABO Type
ABO Type
O
A
B
AB
O
A or B
O
O
A
A
O
O
A
A
B
O
A
O
B
AB
A
A
B
A or B
D-incompatible transplant
Recipient Pre-Transplant
HPC Donor
Component
D-positive
D-negative
D-negative
D-negative
D-positive
D-positive or D-negative
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