Children are more likely than adults to experience complications during apheresis. Michon et al identified the major complications and the risk factors for their occurrence. The authors are from the University of Montreal.


The most common complications seen in children involved:

(1) hypocalcemia associated with citrate toxicity

(2) related to vascular access (thrombosis, catheter-related infection, hematoma, bleeding)

(3) shifts in intravascular volumes


Risk factors for these complications identified on multivariate analysis:

(1) lower body weight (associated with younger age)

(2) lower hemoglobin prior to apheresis

(3) apheresis while in the intensive care unit (ICU)

(4) total number of procedures performed



• Precise cutoffs were not provided.

• For weight < 20 kilograms will be used.

ª For hemoglobin < 8 g/dL was used (the cutoff used for blood priming).

• For total procedures >= 5 was selected arbitrarily.


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