Vitrano et al reported three scores for evaluating a patient with a thalassemia syndrome. One score evaluates a patient with a non-transfusion-dependent phenotype who received transfusions. The authors are from multiple institutions in Italy, Iran, Egypt, Pakistan, Oman, South Africa and Saudi Arabia.
Patient selection: non-transfusion-dependent thalassemia, received transfusions
Outcome: one or more complications
Parameters:
(1) age in years
(2) age at first chelation (in months)
(3) serum ALT in IU/L
(4) left ventricular ejection fraction (LVEF) in percent (from 0 to 100)
Parameter
Points
age in years
0.060 * (age)
age at first chelation
-0.002 * (months)
serum ALT
0.031 * (ALT)
LVEF
-0.114 * (LVEF)
risk score =
= SUM(points for all of the parameters) + 5.542
Risk Score
Risk Group
< 0.49
low
0.49 to 0.81
intermediate
0.82 to 0.94
high
>= 0.95
very high
Performance:
• The area under the ROC curve is 0.83.
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