Complication Risk Scores of Vitrano et al for a Patient with Thalassemia: Non-Transfusion-Dependent Thalassemia (NTDT) Not Receiving Transfusion

Description

Vitrano et al reported three scores for evaluating a patient with a thalassemia syndrome. One score evaluates a patient with a non-transfusion-dependent phenotype who has not been transfused. The authors are from multiple institutions in Italy, Iran, Egypt, Pakistan, Oman, South Africa and Saudi Arabia.

Patient selection: non-transfusion-dependent thalassemia, non-transfused

Outcome: one or more complications

Parameters:

(1) age in years

(2) serum ferritin in ng/mL

(3) left ventricular ejection fraction (LVEF) in percent (from 0 to 100)

Parameter	Points
age in years	0.057 * (age)
serum ferritin	0.002 * (ferritin)
LVEF	-0.074 * (LVEF)

risk score =

= SUM(points for all of the parameters) + 2.177

Risk Score	Risk Group
< 0.18	low
0.18 to 0.39	intermediate
0.40 to 0.92	high
>= 0.83	very high

Performance:

• The area under the ROC curve is 0.80.

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Complication Risk Scores of Vitrano et al for a Patient with Thalassemia: Non-Transfusion-Dependent Thalassemia (NTDT) Not Receiving Transfusion

Description

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