A fibroadenoma is a benign biphasic tumor composed of epitheal and stromal elements. A complex fibroadenoma is a fibroadenoma that contains one or more "complex" features.


Complex features include:

(1) epithelial calcifications

(2) papillary apocrine metaplasia

(3) sclerosing adenosis

(4) cysts > 3 mm


A fibroadenoma is associated with a 2 fold greater risk for invasive breast cancer. The risk is further increased with:

(1) presence of complex features

(2) proliferative changes in parenchyma adjacent to the fibroadenoma

(3) presence of atypical hyperplasia in or adjacent to the fibroadenoma


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