A patient with primary biliary cirrhosis (PBC) may or may not respond to therapy with ursodeoxycholic acid.
Criteria for complete response to therapy - both of the following:
(1) normalization of serum hepatic enzymes (GGT, alkaline phosphatase, etc)
(2) absence of progression to cirrhosis
Criteria for incomplete response to therapy - one or both of the following:
(1) failure of serum hepatic enzymes (GGT, alkaline phosphatase, etc) to return to normal
(2) progression to cirrhosis
• In theory there could be a category for nonresponders - someone whose serum hepatic enzymes increase while on therapy.
• If a patient has cirrhosis when therapy is started, then only the changes in serum liver enzymes can be used as a criterion.
Serum enzymes which can be monitored:
(2) alkaline phosphatase
(5) glutamate dehydrogenase
To read more or access our algorithms and calculators, please log in or register.
Specialty: Gastroenterology, Immunology/Rheumatology