A patient with primary biliary cirrhosis (PBC) may or may not respond to therapy with ursodeoxycholic acid.


Criteria for complete response to therapy - both of the following:

(1) normalization of serum hepatic enzymes (GGT, alkaline phosphatase, etc)

(2) absence of progression to cirrhosis


Criteria for incomplete response to therapy - one or both of the following:

(1) failure of serum hepatic enzymes (GGT, alkaline phosphatase, etc) to return to normal

(2) progression to cirrhosis



• In theory there could be a category for nonresponders - someone whose serum hepatic enzymes increase while on therapy.

• If a patient has cirrhosis when therapy is started, then only the changes in serum liver enzymes can be used as a criterion.


Serum enzymes which can be monitored:

(1) GGT

(2) alkaline phosphatase

(3) ALT

(4) AST

(5) glutamate dehydrogenase


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