The COMPERA 2.0 study reported a four-tier risk stratification model for patients with pulmonary arterial hypertension (PAH). The authors are from numerous institutions in Europe.
Patient selection: adult with mean age 61 +/- 15 years with pulmonary arterial hypertension
Parameters:
(1) WHO functional class for PAH
(2) 6MWD in meters
(3) serum BNP in ng/L
(4) serum NT-proBNP in ng/L
Parameter
Finding
Points
WHO functional class
I or II
1
III
3
IV
4
6MWD
> 440 meters
1
320 to 440 meters
2
165 to 320 meters
3
< 165 meters
4
serum BNP
< 50 ng/L
1
50 to 199 ng/L
2
200 to 800 ng/L
3
> 800 ng/L
4
serum NT-proBNP
< 300 ng/L
1
300 to 649 ng/L
2
650 to 1,100 ng/L
3
> 1,100 ng/L
4
total score =
= SUM(points for all of the parameters)
average score =
= (total score) / 4
Interpretation:
• minimum total score: 4
• maximum total score: 16
• minimum average score: 1
• maximum average score: 4
• The prognosis varied between baseline and follow-up assessments.
Average Score
Risk
5-Year Survival (baseline score)
< 1.5
low
75%
1.5 to 2.49
intermediate-low
65%
2.5 to 3.49
intermediate-high
44%
>= 3.50
high
31%
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