Gerotziafas et al developed a score for determining the risk of thrombosis in a patient with cancer. This can help to identify a patient who may benefit from more aggressive management. The authors are from multiple hospitals in France, the Middle East and the United States.
COMPASS stands for Prospective Comparion of Method for thromboembolic risk assessment with clinical perceptions and awareness in real life patients.
Patient selection: breast, colorectal, lung or ovarian cancer
Exclusion: therapy with low-molecular weight heparin
Outcome: thrombosis
Parameters:
(1) chemotherapy
(2) time since cancer diagnosis
(3) central venous catheter (CVC)
(4) stage of cancer
(5) number of cardiovascular risk factors (see below)
(6) recent hospitalization for acute medical illness
(7) personal history of venous thromboembolism
(8) platelet count
Cardiovascular risk factors:
(1) personal history of peripheral artery disease
(2) ischemic stroke
(3) coronary artery disease
(4) hypertension
(5) hyperlipidemia
(6) diabetes
(7) obesity
|
Parameter
|
Finding
|
Points
|
|
chemotherapy
|
anthracycline therapy
|
6
|
|
|
anti-hormonal therapy for ER-positive breast cancer
|
6
|
|
|
other
|
0
|
|
time since cancer diagnosis
|
<= 6 months
|
4
|
|
|
> 6 months
|
0
|
|
central venous catheter
|
absent
|
0
|
|
|
present
|
3
|
|
cancer stage
|
not advanced or metastatic
|
0
|
|
|
locally advanced or metastatic
|
2
|
|
cardiovascular risk factors
|
0 or 1
|
0
|
|
|
2 or more
|
5
|
|
recent hospitalization
|
no
|
0
|
|
|
yes
|
5
|
|
personal history of venous thromboembolism
|
no
|
0
|
|
|
yes
|
1
|
|
platelet count
|
< 350,000 per µL
|
0
|
|
|
>= 350,000 per µL
|
2
|
total score =
= SUM(points for all 8 parameters)
Interpretation:
• minimum score: 0
• maximum score: 28
• A score >=7 indicates a high risk for venous thromboembolism.
Performance:
• The area under the ROC curve is 0.85.
