Pemphigus is an autoimmune disorder which may have a number of comorbid conditions. These may complicate management of the pemphigus, especially when it is severe.
Comorbid conditions can be divided into:
(1) autoimmune
(2) infectious
(3) malignancies
(4) other
Autoimmune disorders associated with pemphigus:
(1) Hashimoto's thyroiditis with hypothyroidism
(2) type I diabetes
(3) rheumatoid arthritis
(4) alopecia areaata
(5) mysasthena gravis
(6) scleroderma
(7) SLE
(8) autoimmune adrenal insufficiency
(9) vitiligo
(10) inflammatory bowel disease
Infections associated with pemphigus:
(1) herpesvirus
(2) fungal
(3) other viral infection
Immunosuppression and corticosteroid therapy may worsen infections.
Malignancies associated with pemphigus (raising the possibility of paraneoplastic disease):
(1) non-Hodgkin's lymphoma
(2) CLL or other leukemia
(3) squamous cell carcinoma
(4) adenocarcinoma
(5) malignant melanoma
(6) soft tissue tumor
(7) thymoma
Other:
(1) hidradenitis
(2) mucositis
(3) Cushing syndrome
