Pemphigus is an autoimmune disorder which may have a number of comorbid conditions. These may complicate management of the pemphigus, especially when it is severe. 

Comorbid conditions can be divided into:

(1) autoimmune

(2) infectious

(3) malignancies

(4) other


Autoimmune disorders associated with pemphigus:

(1) Hashimoto's thyroiditis with hypothyroidism

(2) type I diabetes

(3) rheumatoid arthritis

(4) alopecia areaata

(5) mysasthena gravis

(6) scleroderma

(7) SLE

(8) autoimmune adrenal insufficiency

(9) vitiligo

(10) inflammatory bowel disease


Infections associated with pemphigus:

(1) herpesvirus

(2) fungal

(3) other viral infection


Immunosuppression and corticosteroid therapy may worsen infections.


Malignancies associated with pemphigus (raising the possibility of paraneoplastic disease):

(1) non-Hodgkin's lymphoma

(2) CLL or other leukemia

(3) squamous cell carcinoma

(4) adenocarcinoma

(5) malignant melanoma

(6) soft tissue tumor

(7) thymoma



(1) hidradenitis

(2) mucositis

(3) Cushing syndrome

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