The Common Toxicity Criteria (CTC) define adverse events following cancer therapy. It was designed for use in clinical trials of different therapeutic regimens.
Types of musculoskeletal adverse events:
(1) arthritis (pain with inflammation, erythema and/or joint swelling)
(2) muscle weakness (not due to neuropathy)
(3) myositis (inflammation and damage of muscle with elevated CPK)
(4) osteonecrosis (avascular necrosis)
(5) other
NOTES:
(1) Arthralgia (joint pain without signs of inflammation) is graded in the "Pain" category.
(2) Myalgia is graded in the "Pain" category.
Grade 0: normal or no change
Parameter |
Finding |
Grade |
arthritis |
none |
0 |
|
mild pain; does not interfere with function |
1 |
|
pain interferes with function but not ADL |
2 |
|
pain interferes with function and ADL |
3 |
|
disabling |
4 |
muscle weakness |
none |
0 |
|
asymptomatic with weakness on physical exam |
1 |
|
symptomatic; interferes with function but not ADL |
2 |
|
symptomatic; interferes with ADL |
3 |
|
bedridden or disabling |
4 |
myositis |
none |
0 |
|
mild pain; does not interfere with function |
1 |
|
pain interferes with function but not ADL |
2 |
|
pain interferes with function and ADL |
3 |
|
bedridden or disabling |
4 |
osteonecrosis |
none |
0 |
|
asymptomatic and detected by imaging only |
1 |
|
symptomatic; interferes with function but not ADL |
2 |
|
symptomatic; interferes with ADL |
3 |
|
bedridden or disabling |
4 |
other |
none |
0 |
|
mild |
1 |
|
moderate |
2 |
|
severe |
3 |
|
life-threatening or disabling |
4 |
where:
• ADL = activities of daily living
Specialty: Hematology Oncology, Surgery, orthopedic