Common Toxicity Criteria (CTC) for Hematology Complications Associated with Cancer Therapy

Parameter

Finding

Points

bone marrow cellularity

normal for age

0

mildly hypocellular or <= 25% reduction from normal cellularity for age

1

moderately hypocellular or 25.1 - 50% reduction from normal cellularity for age or 2.01-3.99 weeks to recover normal cellularity for age

2

severely hypocellular or 50.1 - 75% reduction in cellularity for age or 4-6 weeks to recover normal cellularity for age

3

aplasia or > 75% reduction in cellularity or > 6 weeks required to recover normal cellularity

4

CD4 count

normal

0

500 to < LLN per µL

1

200 - 499 per µL

2

50 - 199 per µL

3

< 50 per µL

4

haptoglobin

normal

0

decreased

1

absent

3

hemoglobin

normal

0

10 g/dL to < LLN

1

8.0 - 9.9 g/dL

2

6.5 - 7.9 g/dL

3

< 6.5 g/dL

4

hemolysis

none

0

only laboratory evidence of hemolysis

1

evidence of red cell destruction and >= 2 gram decrease in hemoglobin without need to transfuse

2

requires transfusion and/or medical intervention

3

catastrophic consequences of hemolysis

4

WBC count

normal

0

3,000 per µL to LLN

1

2,000 - 2,999 per µL

2

1,000 - 1,999 per µL

3

< 1,000 per µL

4

lymphopenia

normal

0

1,000 per µL to LLN

1

500 - 999 per µL

2

< 500 per µL

3

absolute neutrophil count

normal

0

1,500 - 1,999 per µL

1

1,000 - 1,499 per µL

2

500 - 999 per µL

3

< 500 per µL

4

platelet count

normal

0

75,000 per µL to LLN

1

50,000 - 74,999 per µL

2

10,000 - 49,999 per µL

3

< 10,000 per µL

4

platelet transfusion

none

0

yes