The Common Toxicity Criteria (CTC) define adverse events following cancer therapy. It was designed for use in clinical trials of different therapeutic regimens. It can be used to grade endocrine complications..
Types of endocrine complications:
(1) Cushingoid appearance
(2) change in gender appearance (feminization of male, masculinization of female)
(3) gynecomastia
(4) hot flashes or flushes
(5) hypothyroidism
(6) syndrome of inappropriate antidiuretic hormone (SIADH)
(7) other endocrine abnormality
|
Complication |
Finding |
Grade |
|
Cushingoid appearance |
absent |
0 |
|
|
present |
2 |
|
change in gender appearance |
absent |
0 |
|
|
present |
3 |
|
gynecomastia |
none |
0 |
|
|
mild |
1 |
|
|
pronounced or painful |
2 |
|
|
requires surgery |
3 |
|
hot flashes or flushes |
none |
0 |
|
|
mild or no more than 1 per day |
1 |
|
|
moderate and > 1 per day |
2 |
|
hypothyroidism |
none |
0 |
|
|
asymptomatic; TSH elevated but no therapy needed |
1 |
|
|
symptomatic, or thyroid replacement therapy given |
2 |
|
|
symptoms require hospitalization |
3 |
|
|
myxedema coma |
4 |
|
SIADH |
absent |
0 |
|
|
present |
3 |
|
other endocrinopathy |
none |
9 |
|
|
mild |
1 |
|
|
moderate |
2 |
|
|
severe |
3 |
|
|
life-threatening or disabling |
4 |
Specialty: Hematology Oncology, Endocrinology
