Guha et al developed several discriminant functions for evaluating patients with nonalcoholic steatohepatitis and chronic liver disease. The authors are from the University of Southampton, Newcastle University and University Hospital Nottingham in England.
Patient selection: chronic liver disease, nonalcoholic liver disease
Outcome: significant hepatic fibrosis
Difference from simple panels: ELF discriminant score replaces age in years
Parameters:
(1) ELF discriminant score
(2) body mass index in kg per square meter
(3) diabetes or impaired fasting glucose (no = 0, yes = 1)
(4) AST to ALT ratio
(5) platelet count in 10^9/L
(6) serum albumin in g/L
score for any fibrosis =
= (0.062 * (BMI)) + (1.241 * (points for diabetes)) - (0.59 * (AST to ALT ratio)) + (1.482* (ELF)) - (0.002 * (platelet count)) - (0.043 * (albumin)) - 2.722
score for moderate fibrosis =
= (0.084 * (BMI)) + (1.848 * (points for diabetes)) - (1.839 * (AST to ALT ratio)) + (2.408 * (ELF)) - (0.012 * (platelet count)) + (0.141 * (albumin)) - 5.257
score for severe fibrosis =
= (-0.058 * (BMI)) + (4.513 * (points for diabetes)) - (3.144 * (AST to ALT ratio)) + (5.506 * (ELF)) - (0.026 * (platelet count)) + (0.639 * (albumin)) - 20.87
|
Score
|
Cutoff
|
Negative PV
|
Positive PV
|
|
any
|
-5.002
|
0.86
|
0.66
|
|
any
|
-3.346
|
0.69
|
0.87
|
|
moderate
|
-0.995
|
0.94
|
0.75
|
|
moderate
|
-0.016
|
0.90
|
0.81
|
|
severe
|
-0.2826
|
0.77
|
0.99
|
|
severe
|
0.0033
|
0.70
|
1.00
|
