Cognitive and psychiatric disturbances are common manifestations of the neurodegeneration that occurs in Huntington's chorea. These may be the initial presenting features of the disorder.
(1) subcortical dementia with impaired executive functioning (planning, organizing, judging, etc)
(2) impaired working memory (forgetfulness) with preserved long-term memory
(3) disordered sleep
(4) loss of concentration
(5) inflexibility (fixed thoughts)
(6) anosognosia (lack of awareness of defects)
• Lesions in the caudate nucleus disconnect the frontal cortex and result in the deterioration in executive functioning.
(1) personality change
(3) depression (with tendency to suicide)
(6) irritability and aggression
(9) loss of interest and apathy
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Specialty: Genetics, Neurology