A liver transplant may significantly impact production of some coagulation factors. Some patients develop a coagulation deficiency after a liver transplant.


(1) no evidence of a coagulation factor deficiency prior to the liver transplant

(2) presence of the deficiency after the liver transplantation


This has been reported for:

(1) Factor VIII

(2) Factor XI

(3) Factor VII

(4) Factor XII


There are 2 possible mechanisms:

(1) the liver donor had an unrecognized coagulation factor deficiency with deficient production by the liver

(2) production an anti-factor antibody, possibly by lymphocytes in the transplanted liver


Differential diagnosis:

(1) consumptive coagulopathy related to rejection or infection

(2) unrecognized factor deficiency in the recipient unmasked by the transplant

To read more or access our algorithms and calculators, please log in or register.