CNS Penetration Effectiveness (CPE) Score for Antiretroviral Drug Regimen

Purpose: To determine the CNS Penetration Effectiveness (CPE) score for an antiretroviral drug regimen.

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Evaluation

Are you evaluating an HIV drug regimen?

Yes

Number of drugs in the regimen

Number of drugs showing poor penetration into the CNS OR poor effectiveness on CSF viral load

Number of drugs showing good penetration into the CNS AND good effectiveness on CSF viral load

Results

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Results Interpretation and Description References Next Steps

Data complete?

Evaluation appropriate?

CPE rank for the drug regimen

Maximum possible CPE rank for the number of drugs in the regimen

Is the regimen likely to be effective in preventing or treating HIV-related neurocognitive disorder?

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Interpretation and Description

References

Next Steps in Evaluation

Diagnosis

Risk Factors
Other Testing
- Drug Burden Index (DBI) (Total Drug Burden, TDB)
Criteria For Diagnosis
- 1997 Beers Diagnosis Independent Criteria to Identify Potentially Inappropriate Drug Use In an Elderly Patient
Severity, Prognosis, Stage
- Cough & Cold Remedy | Risk Factors for Complications in Pediatric Patient
- Risk Factors for High-Level Polypharmacy in Elderly Hospital Patient
Complications
- Cough & Cold Remedy | Risk Factors for Complications in Pediatric Patient

Therapy

Selection
- Identifying Unnecessary Antibiotic Usage Near End of Life
Pharmacogenetics
- Clinical Utility Score of Kain
- Potentially High Risk Medications
Drug Interactions
Dosage Calculations
- Clinical Utility Score of Kain
- Listing of Drugs with Narrow Therapeutic Index
Dosage Adjustments
- Clinical Utility Score of Kain
- Listing of Drugs with Narrow Therapeutic Index
Administration
- Risk Factors for High-Level Polypharmacy in Elderly Hospital Patient
Failure Handling And Therapy Escalation
- Deprescribing
Prevention
- Medications to Avoid in a Patient at Risk for Delirium

Monitoring

Adverse Effects
Drug Levels
Compliance/adherence
- Pseudopolypharmacy
- Drug Burden Index (DBI) (Total Drug Burden, TDB)
Overdose And Reversal
Complication Detection
- Medication Appropriateness Index

Specialty

Pharmacology, clinical

Objective

dosage adjustments
administration

ICD-10

B20-B24 - Human immunodeficiency virus [HIV] disease
B33.3 - Retrovirus infections, not elsewhere classified

Info

Purpose: To determine the CNS Penetration Effectiveness (CPE) score for an antiretroviral drug regimen.

Specialty: Pharmacology, clinical

Objective: dosage adjustments, administration

ICD-10: B20-B24, B33.3,

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