Clues Associated with Lipodystrophy

 

Clinical and laboratory findings that may be clues for lipodystrophy:

(1) focal or generalized loss of subcutaneous fat

(2) diabetes mellitus with severe insulin resistance (acanthosis nigricans, need for high doses of insulin for glucose control)

(3) hypertriglyceridemia (serum triglycerides >= 500 mg/dL) poorly responsive to diet and/or medical therapy with or without pancreatitis

(4) nonalcoholic steatohepatitis (NASH)

(5) family history of similar findings

(6) disproportionate hyperphagia

(7) male with secondary hypgonadism

(8) female with amenorrhea and/or polycystic ovary syndrome (PCOS)

(9) prominent muscularity with enlarged veins (phlebomegaly) in the extremities