Hoechstetter et al reported a prognostic model for patients with chronic lymphocytic leukemia (CLL) at Binet Stage A. The data was collected in the CLL1 trial. The authors are from the German CLL Study Group.
Patient selection: CLL with age <= 75 years, ECOG 0 or 1, Binet stage A
Parameters:
(1) age of the patient in years
(2) lymphocyte double time (LDT) in months
(3) serum beta-2 microglobulin in mg/L
(4) del(11q)
(5) del(17p)
(6) mutation status of IGHV (immunoglobulin heavy chain variable gene)
Parameter
Finding
Points
age in years
<= 60 years
0
> 60 years
1.5
LDT in months
< 12 months
1.5
0
>= 12 months
0
serum beta-2 microglobulin
<= 3.5 mg/L
0
> 3.5 mg/L
2.5
del(11q)
absent
0
present
2.5
del(17p)
absent
0
present
3.5
IGHV
unmutated
2.5
mutated
0
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 14
Total Score
Risk Group
Cumulative Survival at 10 Years
0 to 1.5
very low
90%
2 to 4
low
73%
4.5 to 6.5
high
40%
>= 7
very high
18%
Performance:
• The area under the ROC curve for time to first treatment (TTFT) was 0.72.
To read more or access our algorithms and calculators, please log in or register.
