Matutes et al reported a simple score for the diagnosis of chronic lymphocytic leukemia (CLL) based on immunofluorescent membrane markers. The authors are from the Royal Marsden Hospital and Institute of Cancer Research in London.
Patient selection: malignant lymphocytosis
Parameters:
(1) surface immunoglobulins
(2) CD5
(3) CD23
(4) FMC7
(5) CD22
Parameter
Finding
Points
surface immunoglobulin
absent
0
present
1
CD5
absent
0
present
1
CD23
absent
0
present
1
FMC7
absent
0
present
1
CD22
absent
0
present
1
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• A score of 4 or 5 is seen with CLL (seen in 87% of CLL patients).
• A score of 3 is possibly CLL (seen in 10% of CLL patients).
• A score of 0 to 2 is probably another diagnosis (0.4% score 0 or 1; 3% score 2).
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