The signs and symptoms of hypopituitarism differ in adults depends on the severity of the pituitary involvement.


Endrocrine axes that may be affected:

(1) corticotropin

(2) thyrotropin

(3) growth hormone

(4) gonadotropin

(5) vasopressin


Features of corticotropin deficiency (adrenocortical insufficiency0:

(1) fatigue, tiredness and weakness

(2) dizziness

(3) nausea and vomiting

(4) anorexia and weight loss

(5) pallor

(6) hypoglycemia

(7) circulatory collapse


Features of thyrotropin deficiency (hypothyroidism):

(1) decreased sweating

(2) coarse, dry skin

(3) cold intolerance/sensitivity

(4) constipation

(5) hoarseness

(6) decreased hearing

(7) slow movements

(8) decreased deep tendon reflexes

(9) paresthesias

(10) bradycardia


Features of growth hormone deficiency:

(1) decreased muscle mass and strength

(2) central obesity

(3) fatigue

(4) premature atherosclerosis


Features of gonadotropin and androgen deficiency:

(1) impaired fertility

(2) decreased libido

(3) osteoporosis

(4) decreased muscle mass

(4) amenorrhea or oligomenorrhea, dyspareunia (females)

(5) decreased hair growth (males)


Features of vasopressin deficiency (diabetes insipidus):

(1) large volumes of urine with a low osmolality


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