The signs and symptoms of hypopituitarism differ in adults depends on the severity of the pituitary involvement.
Endrocrine axes that may be affected:
(1) corticotropin
(2) thyrotropin
(3) growth hormone
(4) gonadotropin
(5) vasopressin
Features of corticotropin deficiency (adrenocortical insufficiency0:
(1) fatigue, tiredness and weakness
(2) dizziness
(3) nausea and vomiting
(4) anorexia and weight loss
(5) pallor
(6) hypoglycemia
(7) circulatory collapse
Features of thyrotropin deficiency (hypothyroidism):
(1) decreased sweating
(2) coarse, dry skin
(3) cold intolerance/sensitivity
(4) constipation
(5) hoarseness
(6) decreased hearing
(7) slow movements
(8) decreased deep tendon reflexes
(9) paresthesias
(10) bradycardia
Features of growth hormone deficiency:
(1) decreased muscle mass and strength
(2) central obesity
(3) fatigue
(4) premature atherosclerosis
Features of gonadotropin and androgen deficiency:
(1) impaired fertility
(2) decreased libido
(3) osteoporosis
(4) decreased muscle mass
(4) amenorrhea or oligomenorrhea, dyspareunia (females)
(5) decreased hair growth (males)
Features of vasopressin deficiency (diabetes insipidus):
(1) large volumes of urine with a low osmolality
Specialty: Endocrinology, Clinical Laboratory, Neurology, Immunology/Rheumatology
ICD-10: ,