Huang et al reported a clinical score for evaluating a pediatric patient for hand-foot-mouth disease. The authors are from the Affiliated Children's Hospital, Capital Institute of Pediatrics, in Beijing.
Causes of hand-foot-mouth disease: enterovirus 71, coxsackievirus group A4 (plus others)
Patient selection: child under 3 years of age with an acute rash
Parameters:
(1) age in years
(2) exposure history
(3) hard palate rash count
(4) soft palate rash count
(5) buccal mucosa rash count
(6) back rash count
(7) buttocks rash count
Parameter
Finding
Points
age in years
0
0
1
1
2
2
exposure history
no
0
yes
7
hard palate
none
0
few
3
many
3
soft palate
none
0
few
2
many
4
buccal mucosa
none
0
few
2
many
3
back rash
none
0
few
-2
many
-5
buttocks rash
none
0
few
3
many
5
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: -5
• maximum score: 24
• A score >= 7 has a sensitivity of 76% and specificity of 68%.
Total Score
Probability
<= 6
53%
7 to 11
81%
12 to 24
94%
Performance:
• The area under the ROC curve is 0.80 in the training set and 0.76 in the validation set.
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