Foucher et al reported a score for predicting long-term renal transplant survival. This can help to identify a patient who may require more aggressive management. The authors are from multiple institutions in France.
Patient selection: renal transplant recipient
Parameters:
(1) blood creatinine of donor in µmol/L
(2) age of the recipient in years
(3) number of previous transplantations (not defined; presumably renal)
(4) acute rejection in first year after transplant
(5) blood creatinine at 3 months after transplant in µmol/L
(6) blood creatinine at 12 months after transplant in µmol/L
(7) gender
(8) proteinuria in g/day at 1-year post-transplant
|
Parameter
|
Finding
|
Points
|
|
donor creatinine
|
<= 190 µmmol/L
|
0
|
|
|
> 190 µmol/L
|
-0.75072
|
|
age of recipient
|
<= 25 years
|
0
|
|
|
> 25 years
|
-1.02316
|
|
number of previous transplants
|
<= 2
|
0
|
|
|
> 2
|
1.17295
|
|
acute rejection
|
no
|
0
|
|
|
yes
|
0.22288
|
|
creatinine at 3 months
|
|
0.01881 * (creatinine)
|
|
creatinine at 12 months
|
|
0.41551 * SQRT(creatinine)
|
|
gender
|
female
|
0
|
|
|
male
|
-0.88001
|
|
proteinuria
|
female
|
(0.61121 * (protein)) + (0.04077 * ((protein)^2))
|
|
|
male
|
(1.09722 * (protein)) - (0.02038 * ((protein)^2))
|
where:
• Male proteinuria points are derived from: (0.61121 * (protein)) + (0.04077 * ((protein)^2)) + (0.48601 * (protein)) - (0.06115 * ((protein)^2))
KTFSat one year =
= SUM(points for all of the parameters)
|
KTFS
|
Grade
|
Graft Failure Rate at 8 Years
|
|
<= 4.17
|
I
|
7%
|
|
> 4.17
|
II
|
30%
|
Performance:
• The area under the ROC curve is 0.78.
