Chen et al developed a simple score for predicting the risk of severe coronary artery disease (CAD) in a patient prior to elective coronary angiography. The authors are from Fudan University and Tongji University in Shanghai.
Patient selection: stable angina
Parameter:
(1) aortic valve calcification
(2) ECG
(3) diabetes
(4) gender
(5) hyperlipidemia
(6) LDL-C in mmol/L
(7) HDL-C in mmol/L
(8) age in years
Parameter |
Finding |
Points |
aortic valve calcification |
no |
0 |
|
yes |
3 |
ECG |
normal |
0 |
|
abnormal |
3 |
diabetes |
no |
0 |
|
yes |
2 |
gender |
female |
0 |
|
male |
2 |
hyperlipidemia |
no |
0 |
|
yes |
2 |
LDL-C |
< 1.8 mmol/L |
0 |
|
1.8 to 2.2 mmol/L |
1 |
|
> 2.2 |
2 |
HDL-C |
>1.2 mmol/L |
0 |
|
1.0 to 1.2 mmol/L |
1 |
|
< 1.0 mmol/L |
2 |
age in years |
< 65 years |
0 |
|
>= 65 years |
2 |
where:
• The point assignment overlapped for LCL-C at 2.2 and HDL-C at 1.2.
total score =
= SUM(points for all 8 parameter)
Interpretation:
• minimum score: 0
• maximum score: 18
• The higher the score the greater the risk of severe CAD at angiography.
Score |
Risk of Severe Coronary Artery Disease |
0 to 5 |
(0.3571 * ((score)^2)) + (3.157 * (score)) + 12.4 |
5 to 13 |
(-0.2484 * ((score)^2)) + (10.48 * (score)) - 9.704 |
13 to 15 |
(-0.2679 * ((score)^2)) + (10.45 * (score)) - 6.29 |
Performance:
• The area under the ROC curve ranged from 0.74 (training set) and 0.71 (validation set).
Specialty: Cardiology