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Description

Chen et al developed a simple score for predicting the risk of severe coronary artery disease (CAD) in a patient prior to elective coronary angiography. The authors are from Fudan University and Tongji University in Shanghai.


Patient selection: stable angina

 

Parameter:

(1) aortic valve calcification

(2) ECG

(3) diabetes

(4) gender

(5) hyperlipidemia

(6) LDL-C in mmol/L

(7) HDL-C in mmol/L

(8) age in years

 

Parameter

Finding

Points

aortic valve calcification

no

0

 

yes

3

ECG

normal

0

 

abnormal

3

diabetes

no

0

 

yes

2

gender

female

0

 

male

2

hyperlipidemia

no

0

 

yes

2

LDL-C

< 1.8 mmol/L

0

 

1.8 to 2.2 mmol/L

1

 

> 2.2

2

HDL-C

>1.2 mmol/L

0

 

1.0 to 1.2 mmol/L

1

 

< 1.0 mmol/L

2

age in years

< 65 years

0

 

>= 65 years

2

 

where:

• The point assignment overlapped for LCL-C at 2.2 and HDL-C at 1.2.

 

total score =

= SUM(points for all 8 parameter)

 

Interpretation:

• minimum score: 0

• maximum score: 18

• The higher the score the greater the risk of severe CAD at angiography.

 

Score

Risk of Severe Coronary Artery Disease

0 to 5

(0.3571 * ((score)^2)) + (3.157 * (score)) + 12.4

5 to 13

(-0.2484 * ((score)^2)) + (10.48 * (score)) - 9.704

13 to 15

(-0.2679 * ((score)^2)) + (10.45 * (score)) - 6.29

 

Performance:

• The area under the ROC curve ranged from 0.74 (training set) and 0.71 (validation set).


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