Starkman et al reported a prognostic score for a patient with the myelodysplastic syndrome (MDS). The authors are from multiple institutions in Canada.
Patient selection: myelodysplasia
Parameters:
(1) age of the patient in years
(2) MDS frailty index of Starkman et al, from 0 to 1
(3) International Prognostic Scoring System (IPSS) for Myelodysplasia
(4) transfusion dependency status
Parameter
Finding
Points
age
< 70 years
0
>= 70 years
0.5
frailty index
<= 0.2
0
0.21 to 0.3
0.5
> 0.3
1
IPSS
low
0
intermediate-1
0.5
intermediate-2
1
high
2
transfusion
independent
0
dependent
0.5
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the worse the overall survival.
• A patient with a score >= 3 has a 4-year overall survival rate that is very low.
Score
Prognostic Group
24-Month Overall Survival
0
1 (very good)
94%
0.5
2 (fair)
74%
1
3
66%
1.5 to 2.5
4
34%
3 to 4
5 (poor)
13%
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