Description

Mahachai et al reported a clinical predictive score for metabolic dysfunction-associated steatotic liver disease (MASLD) in a patient with prediabetes. The authors are from Mahidol University in Bangkok.


Patient selection: pre-diabetic with metabolic syndrome

 

Parameters:

(1) fasting plasma glucose in mg/dL

(2) hemoglobin A1c in percent

(3) serum HDL cholesterol in mg/dL

(4) gender

(5) serum AST in U/L

(6) body mass index (BMI) in kg per square meter

 

Parameter

Finding

Points

fasting plasma glucose

< 110 mg/dL

0

 

>= 110 mg/dL

2

hemoglobin A1c

< 6%

0

 

>= 6%

1.5

serum HDL cholesterol

>= 40 mg/dL and male

0

 

< 40 mg/dL and male

1.5

 

>= 50 mg/dL and female

0

 

< 50 mg/dL and female

1.5

serum AST

< 30 IU/L

0

 

>= 30 IU/L

1.5

body mass index

< 23 kg per sq m

0

 

24 to 24.99 kg per sq m

1

 

>= 25.0 kg per sq m

4

 

total score =

= SUM(points for all of the parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 10.5

• A score >= 4.5 is associated with a higher risk for steatotic liver disease.

• Hepatic transient elastography may be performed on high-risk patients. It would not be helpful in the low-risk patient.

Performance:

• The area under the ROC curve is 0.80.

 


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