Name given to clinical prediction rule: Neurological Sequelae due to Acute Encephalopathy (NSAE-CPR)
Patient selection:
(1) pediatric patient < 16 years old with complex febrile seizures
(2) exclusion of epilepsy by history, infection and inherited metabolic disorders
Features of complex febrile seizures - one or more of the following:
(1) partial onset or focal features during the seizure
(2) duration > 15 minutes (prolonged)
(3) recurrent febrile seizure within 24 hours
Outcome: adverse neurological sequelae (intellectual disability, vegetative state)
Predictors of a poor outcome:
(1) refractory status epilepticus (seizure lasting > 60 minutes without response to first-line medications)
(2) consciousness disturbance (GCS <= 14) and/or hemiplegia at 6 hours from onset
(3) serum AST > 90 IU/L within 6 hours of onset (reference range not stated)
where:
• Early elevation of serum AST was associated with metabolic disorder or cytokine storm.
