Morimoto et al reported a clinical prediction rule for angiotensin-Converting Enzyme (ACE) inhibitor-induced cough. The authors are from Brigham and Women's Hospital, Harvard Medical School, and Kyoto University.
Patient selection: on ACE inhibitor (ACEI)
Parameters:
(1) age in years
(2) sex
(3) race or ethnicity
(4) history of ACE inhibitor-induced cough
(5) no history of other ACE inhibitors
Parameters
Findings
Points
age in years
< 60 years
0
60 to 69 years
3
>= 70 years
2
sex
male
0
female
3
race or ethnicity
African-American
0
East Asian (Chinese, Korean, Japanese)
6
neither
2
history of ACEI cough
no
0
yes
13
history of other ACE inhibitors
no
3
yes
0
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 25
Total Score
Percent ACEI Cough
<= 5
4-6%
6 to 8
9-14%
9 to 11
29-22%
>=12
55-60%
Performance:
• The area under the ROC curve is 0.71.
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