Chavanet et al reported a clinical prediction rule referred to as Meningitest which can distinguish bacterial from viral meningitis. The authors are from multiple institutions in France, Spain and the United States.
NOTE: This is distinct from the Meningitest of Dubos et al.
Parameters:
(1) white blood cell count per microliter
(2) CSF leukocyte count per microliter
(3) percent PMNs in the CSF differential count
(4) CSF protein concentration in g/L
(5) ratio of glucose in CSF to blood
ratio of glucose in CSF to blood =
= (CSF glucose in mg/dL) / (blood glucose in mg/dL)
Parameter |
Finding |
Points for Adult (> 15 yo) |
WBC count |
<= 15,000 per µL |
0 |
|
> 15,000 per µL |
3 |
CSF WBC count |
> 1700 per µL |
4 |
|
251 to 1700 |
2 |
|
<= 250 |
1 |
CSF PMNs |
> 90% |
4 |
|
81 to 90% |
2 |
|
26 to 80% |
1 |
|
<= 25% |
0 |
CSF protein |
> 2.3 g/L |
5 |
|
0.81 to 2.3 |
2 |
|
<= 0.8 |
0 |
CSF/blood glucose ratio |
<= 0.35 (< 0.33 in abstract) |
4 |
|
> 0.35 |
0 |
total score for an adult =
= SUM(points for all 5 parameters)
Parameter |
Finding |
Points for Child (> 3 months to 15 yo) |
CSF WBC count |
>= 1800 per µL |
2 |
|
< 1800 |
0 |
CSF PMNs |
> 80% |
3 |
|
<= 80% |
0 |
CSF protein |
> 1.2 g/L |
3 |
|
<= 1.2 g/L |
0 |
CSF/blood glucose ratio |
<= 0.3 (< 0.3 in abstract) |
3 |
|
> 0.3 |
0 |
total score for a child =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score for an adult: 1
• maximum score for an adult: 20
• A score >= 6 for an adult indicates bacterial meningitis.
• minimum score for a child: 0
• maximum score for a child: 11
• A score >= 2 for a child indicates bacterial meningitis.
Specialty: Infectious Diseases