Clinical Prediction Rule of Brindle et al for Congenital Diaphragmatic Hernia in a Newborn

Description

Brindle et al reported a clinical decision rule for newborn infants with congenital diaphragmatic hernia. This can help to identify a neonate who may require more aggressive management. The authors are from multiple institutions in North America and Europe.

Parameters:

(1) birth weight

(2) 5-minute Apgar score (from 0 to 10)

(3) pulmonary hypertension on echocardiogram

(4) major cardiac anomaly

(5) chromosomal anomaly

Parameter	Finding	Points
birth weight	low (< 1,500 g)	1
	not low	0
Apgar score	low (< 7)	1
	high	0
	missing	2
pulmonary hypertension	severe	2
	none to moderate	0
major cardiac anomaly	no	0
	yes	2
chromosomal anomaly	no	0
	yes	1

total score =

= SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: 8

Total Score	Risk Group	Mortality Rate
0	low	< 10%
1 or 2	intermediate	25%
3 to 8	high	50%

Performance:

• The area under the ROC curve was 0.81 in the derivation set and 0.77 in the validation set.

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Clinical Prediction Rule of Brindle et al for Congenital Diaphragmatic Hernia in a Newborn

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