Colombat et al listed criteria for when to perform a transbronchial biopsy in a patient with a lung transplant. The authors are from Beaujon Hospital in Clichy Cedex, France.


Patient selection: lung transplant


Indications for transbronchial biopsy:

(1) dyspnea that is not otherwise explained (by pneumonia, heart failure, etc)

(2) decrease in FEV1 by >= 11%

(3) decrease in PaO2 by >= 11 mm Hg

(4) chest X-ray abnormal

(5) poor or suboptimal response to antibiotics (presumably with a pulmonary infiltrate)



• The decrease in FEV1 as a decimal fraction is ((baseline) - (current)) / (baseline). Alternatively (baseline FEV1) > 1.11 * (current FEV1)


A patient with one or more of these findings should be considered for transbronchial biopsy and bronchio-alveolar lavage.


To read more or access our algorithms and calculators, please log in or register.