Clinical Indications for Measurement of Anti-Neutrophil Cytoplasmic Antibodies (ANCA)

• chronic destruction of the upper airways?

• chronic sinusitis or otitis?

• subglottic tracheal stenosis?

• retro-orbital mass?

• pulmonary hemorrhage?

• multiple lung nodules?

• glomerulonephritis?

• peripheral neuropathy?

• cutaneous vasculitis with systemic features?

• a known autoimmune disease with ANCA present?

Is there a known non-immune cause (infection, tumor, toxin, etc.)?

Is there evidence of a systemic autoimmune disease?

Are you trying to distinguish between autoimmune disease activity and the effect of cytotoxic therapy?