Hegedus listed several clinical findings which are suspicious for thyroid carcinoma in a euthyroid patient with a solitary thyroid nodule. These can help identify a patient who may benefit from a more complete evaluation. The author is from Odense University Hospital in Denmark.
Clinical Finding |
Level of Risk |
age of the patient < 20 or > 70 years of age |
moderate |
male gender |
moderate |
family history of medullary thyroid carcinoma |
high |
family history of an MEN syndrome |
high |
history of neck irradiation |
moderate |
presence of dysphagia, dysphonia, hoarseness, dyspnea and/or cough |
moderate |
paralysis of the vocal cords |
high |
rapid nodule growth, especially during levothyroxine therapy |
high |
nodule > 4 cm in diameter |
moderate |
nodule that is partially cystic |
moderate |
nodule that is very hard or firm |
high |
nodule fixated to adjacent structures |
high |
regional lymphadenopathy |
high |
distant metastases |
very high |
Specialty: Hematology Oncology, Surgery, general, Endocrinology