Moulis et al reported clinical findings associated with newly diagnosed immune thrombocytopenia (ITP) in adults. The authors are from multiple institutions in France.

Patient selection: adult with new onset of immune thrombocytopenia


Bleeding symptoms:

(1) cutaneous

(2) mucosa of head and neck (epistaxis, oral)

(3) gastrointestinal

(4) hematuria

(5) central nervous system


Key risk factors for the ITP:

(1) autoimmune disease

(2) infection within the 6 weeks prior to onset


Other factors:

(1) myelodysplasia

(2) malignancy

(3) targeted agent (adalimumab)


Predictors of chronic ITP:

(1) antinuclear antibody positive


Predictors of therapy with intravenous corticosteroids (methylprednisolone) and/or intravenous immunoglobulin (IVig):

(1) Khellaf bleeding score > 8 (range 0 to 35)

(2) platelet count <= 10,000 per µL


Criteria for recovery - all of the following:

(1) >= 2 platelet counts >= 150,000 per µL at least 7 days apart

(2) absence of bleeding

(3) absence of ITP treatment

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