Fan et al reported clinical findings that may be seen with central nervous system (CNS) involvement in a patient with primary Sjogren's Syndrome. The authors are from Xiamen Medical College and Yale University.
Patient selection: primary Sjogren's syndrome
More common neurologic manifestations:
(1) hemiparesis
(2) paraparesis
(3) dysphonia
(4) disordered proprioception
(5) blurred vision
Less common neurologic findings:
(1) limb numbness
(2) headache
(3) cognitive impairment
(4) aseptic meningitis
(5) facial paresis
(6) syncope
(7) urination disorders
CNS imaging findings may be found at all levels of the CNS:
(1) cerebral infarction
(2) demyelination
(3) myelitis
(4) angiostenosis
(5) leukoaraiosis (an abnormality of white matter related to poor perfusion)
(6) cerebral ischemia
(7) cerebral hemorrhage
where:
• The presence of infarction or hemorrhage and hemiparesis clinically be a stroke.
• Disordered proprioception, myelitis, limb numbness and urination disorders may correlate with changes in the spinal cord.
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