Description

Tryptamines are a group of synthetic compounds related to psilocybin. These share structural similarities with serotonin.


 

Chemical group: indolealkylamines

 

Derivatives with pharmacologic activity: ethylamine substitutions or indole ring structures

 

Tryptamines include the following (with side chains in parentheses):

(1) AMT (N,N-alpha-methyl)

(2) 5-MeO-AMT (5-methoxy-N,N-alpha)

(3) DPT (N,N-dipropyl)

(4) 5-MeO-DIPT (5-methoxy-N,N-diisopropyl)

(5) 5-MeO-DPT (5-methoxy-N,N-dimethyl)

 

Desirable effects:

(1) euphoria

(2) feelings of empathy

(3) hallucinations

 

Undesirable psychological effects:

(1) auditory hallucinations

(2) visual hallucinations

(3) emotional distress

(4) agitation

(5) confusion

 

Undesirable physiologic effects:

(1) nausea and vomiting

(2) diarrhea

(3) hypertension

(4) tachycardia

(5) diaphoresis (sweating)

(6) salivation

(7) dystonia

(8) mydriasis

(9) tremors

(10) seizures

 

Rare effects:

(1) catalepsy

(2) paralysis

(3) rhabdomyolysis

 

A user may take an MAO inhibitor to increase oral bioavailability, which increases the risk for a drug interaction.

 


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