Acute chest syndrome is one of the complications of sickle cell disease.
Pathogenesis: pulmonary infection, pulmonary fat embolism from necrotic bone marrow and/or pulmonary infarction
Clinical features (vary with age):
(1) acute illness
(3) chest pain
(4) fever (>= 38.5°C)
(8) variable crepitations on auscultation
Findings on imaging studies: segmental pulmonary infiltrate consistent with consolidation
(1) progression to acute respiratory failure
(2) multi-organ failure
(3) neurological complications (stroke, posterior reversible leukoencephalopathy, etc)
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