Chronic Granulomatous Disease (CGD) usually presents in early childhood with recurrent infections.


Key Pathologic feature: infection with catalase-positive bacteria or with fungi


Probable mechanism: defective production of superoxide by neutrophils


Clinical features:

(1) recurrent infections, typically starting during infancy

(2) hepatosplenomegaly

(3) generalized lymphadenopathy

(4) anemia

(5) hypergammaglobulinemia

(6) sites of infection show granulomatous inflammation with lipid-bearing histiocytes


Common organisms associated with infection:

(1) Staphylococcus aureus

(2) Burkholderia

(3) Salmonella species

(4) Nocardia sp

(5) Serratia or other Enterobacteriaceae

(6) Streptococcus

(7) Aspergillus species

(8) Candida species


Infections may occur anywhere in the body:

(1) subcutaneous abscesses

(2) liver abscesses

(3) pneumonia

(4) lung abscess

(5) osteomyelitis with abscess

(6) brain abscess

(7) perirectal abscess

(8) colitis

(9) lymphadenitis

(10) sepsis

(11) post-operative wound infections


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