Description

Acute arsenic poisoning may occur following a significant exposure to inorganic or organic arsenic compounds, with the inorganic salts more toxic.


 

Routes of exposure:

(1) inhalation

(2) ingestion

(3) transdermal

 

Systemic findings

(1) fever

(2) shock

 

Neurologic findings:

(1) tremor

(2) convulsions

(3) coma

 

Gastrointestinal findings:

(1) abdominal pain

(2) nausea and vomiting

(3) dysphagia

(4) diarrhea, bloody or watery or black (if lead arsenate ingested)

(5) irritation to mucous membranes from contact

(6) metallic taste

 

Renal findings:

(1) acute renal failure with oliguria and uremia

 

Respiratory tract (following inhalation):

(1) pharyngitis

(2) acute respiratory failure

 

Ocular changes (from gas or contact):

(1) irritation with conjunctivitis

 

Cardiac findings:

(1) abnormal ST-T waves

(2) prolonged QT interval

(3) ventricular fibrillation

(4) atypical ventricular tachycardia

 

Dermatologic findings:

(1) irritation if skin contact

(2) loss of hair (delayed)

(3) A Mees's line (whitish band) may occur 2-3 weeks post-ingestion. Multiple lines would suggest repeated exposures.

 


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