Uner Tan described a hereditary syndrome of quadrupedalism in several Turkish families. The first patients were described in 1917.


Several families have been identified in different parts of Turkey.


Inheritance: not defined


Clinical features:

(1) consanguinity

(2) quadrupedalism

(3) mental retardation

(4) dysarthria or absence of speech

(5) cerebellar ataxia


So far 2 types have been described, Type I without and Type II with infantile hypotonia.


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