The DREAM-PL syndrome is a rare disorder with congenital microcephaly and lissencephaly.
Chromosome Location: 16q24.3
Gene affected: CTU2 (cytosolic thiouridylase subunit 2) with abnormal t-RNA
Inheritance: autosomal recessive
D: dysmorphic facies (micrognathia, depressed nasal bridge, up-slanting palpebral fissures, other)
RE: renal agenesis
A: ambiguous genitalia (male)
M: microcephaly
P: polydactyly
L: lissencephaly (smooth brain with absence of cerebral gyri)
