Bing and Neel reported a syndrome of neurological involvement in patients with Waldenstrom's macroglobulinemia. This may be associated with a number of neurological signs and symptoms.


The clinical findings may vary depending on whether the neurological involvement is diffuse (primarily meningeal) or as a mass lesion.


Clinical features may include:

(1) peripheral neuropathy (paresthesias, pain)

(2) nuchal rigidity

(3) cerebellar dysfunction, ataxia

(4) cranial neuropathy

(5) nausea and vomiting

(6) confusion, disorientation or altered mental status

(7) hemiparesis

(8) seizures

(9) personality change, mood change or psychiatric symptoms

(10) visual disturbance (visual loss, nystagmus, blurred vision)

(11) headache

(12) aphasia

(13) proximal weakness

(14) memory loss

(15) hearing loss

(16) cauda equina syndrome

(17) dysarthria

(18) fatigue


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