Deficiency of pyridoxine (vitamin B6) is rare. It can result in a variety of clinical findings.
Pathologic changes:
(1) oral
(2) dermal
(3) neurologic
(4) hematologic
Oral changes:
(1) glossitis
(2) angular stomatitis
(3) cheilosis
Skin changes:
(1) seborrheic dermatitis in the nasolabial fold, cheeks, neck, ears, and perineum
(2) blepharitis
where:
• Angular stomatitis = superficial erosions or fissures at the angles of the mouth
• Cheilosis = dry scaling and fissuring of the vermillion surfaces of the lips
• Blepharitis = inflammation of the eyelids
Neurologic changes:
(1) peripheral neuropathy
(2) irritability
(3) seizures in children
(4) depression
(5) confusion
(6) an abnormal EEG
Hematologic change:
(1) hypochromic, microcytic anemia (pyridoxine-responsive)
