Deficiency of pyridoxine (vitamin B6) is rare. It can result in a variety of clinical findings.


Pathologic changes:

(1) oral

(2) dermal

(3) neurologic

(4) hematologic


Oral changes:

(1) glossitis

(2) angular stomatitis

(3) cheilosis


Skin changes:

(1) seborrheic dermatitis in the nasolabial fold, cheeks, neck, ears, and perineum

(2) blepharitis



• Angular stomatitis = superficial erosions or fissures at the angles of the mouth

• Cheilosis = dry scaling and fissuring of the vermillion surfaces of the lips

• Blepharitis = inflammation of the eyelids


Neurologic changes:

(1) peripheral neuropathy

(2) irritability

(3) seizures in children

(4) depression

(5) confusion

(6) an abnormal EEG


Hematologic change:

(1) hypochromic, microcytic anemia (pyridoxine-responsive)


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