medical decision support medical decision support
Sign In

Clinical Features of Paraldehyde Withdrawal

Description

Paraldehyde is a sedative-hypnotic that was administered to chronic alcoholics. Some patients developed a tolerance or addiction to it, using it chronically alone or with other drugs (chronic paraldehydism). Administration was often by rectal enemas. Stopping intake can precipitate withdrawal.


 

Paraldehyde = 2,4,6-trimethyl-1,3,5-trioxane (trioxane = 6 member ring of 3 carbon atoms alternating with 3 oxygen atoms = a polymer of acetaldehyde.

 

Paraldehyde withdrawal may occur by itself, or with alcohol withdrawal, or while intoxicated with other drugs. It may develop in a patient who was admitted to the hospital with paraldehyde intoxication.

 

Tolerance is indicated by the need for higher and more frequent doses to achieve the same effect.

 

Clinical findings in withdrawal (which may overlap with problems of abuse, below):

(1) delirium tremens

(2) hallucinations

(3) tremulousness, agitation and restlessness

(4) anxiety

 

Management is similar to that of alcohol withdrawal, with additional care taken for monitoring the complications associated with chronic use.

 


To read more or access our algorithms and calculators, please log in or register.

Specialty