Orofacial granulomatosis (OFG) is a disorder of uncertain etiology that is associated with a number of clinical findings.


Clinical finding:

(1) facial swelling

(2) swelling of the upper and/or lower lips

(3) mucosal edema

(4) angular cheilitis

(5) oral ulcerations

(6) allergy to food or food additives


A biopsy shows noncaseating granulomas.


Diagnosis requires exclusion of other causes of granulomatous inflammation:

(1) Crohn's disease

(2) sarcoidosis

(3) Melkersson-Rosenthal syndrome

(4) tuberculosis

(5) foreign body reaction

(6) deep fungal infection


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