Neurolymphomatosis refers to infiltration of one or more nerves by malignant lymphoma cells.


Clinical findings:

(1) The patient usually has widespread malignant lymphoma.

(2) The patient may have a cranial or spinal sensorimotor polyneuropathy which may be painful or painless.

(3) Other causes of neuropathy are excluded.


Electromyography shows a polyneuropathy with low amplitude motor action potentials.


A nerve biopsy shows diffuse infiltration of the nerve by lymphoma cells. A muscle biopsy shows neurogenic muscle atrophy.


Differential diagnosis:

(1) peripheral neuropathy associated with chemotherapy

(2) leptomeningeal lymphomatosis


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