carisoprodol = N-isopropyl-meprobamate
Active metabolite: meprobamate
The drug is metabolized by hepatic CYP2C19.
Actions that can trigger withdrawal include:
(1) sudden discontinuation in a person who has been abusng the drug for a long time
(2) exposure to Flumazenil, which blocks GABA-A receptors, may precipitate withdrawal.
(3) drugs that enhance mepromate elimination
Clinical findings during withdrawal:
(1) anxiety and/or depression
(2) tremors or muscle twitchings
(3) body aches, muscle pains (myalgias) and/or arthralgias
(4) restlessness, irritability and agitation
(5) insomnia
(6) diffuse sweating (diaphoresis)
(7) chills
(8) nausea
(9) diarrhea
(10) abdominal cramps
(11) headache
(12) auditory and/or visual hallucinations
(13) bizarre behavior, disorientation and/or delirium
(14) palpitations
(15) cravings
